Re-Emergence of Epizootic Epitheliotropic Disease Virus: Potential Effects & Development of Improved Diagnostics and Control Measures

Grant: # 1455

Grant Amount: $361,150.00

Board Decision Year: 2014

Michigan State University - Pathobiology and Diagnostic Investigation (East Lansing)

Pathobiology and Diagnostic Investigation

Loch, Thomas ([email protected]) 517-353-9323

2014 Ecosystem Health and Sustainable Fish Populations: Ecological and Biological Research to Inform Management - Ecological and biological fisheries research to inform management

Project Details

Salmonid herpesvirus 3, commonly known as epizootic epitheliotropic disease virus (EEDV), is a serious pathogen of lake trout, an indigenous species to the Great Lakes basin. With funding from the Great Lakes Fishery Trust, scientists were able to unravel some of the characteristics of EEDV by documenting two EEDV-associated epidemics in lake trout hatcheries. The study was able to sequence the full virus genome and decipher many of the genes that the genome carries; this will aid in finding potential vaccines effective against EEDV. The study also provided evidence for the host range of EEDV differences between lake trout strains. The project team was able to prepare virus-rich tissue homogenates from infected fish and used the material to standardize intraperitoneal and water-borne experimental infection protocol. The study increased the general knowledge of EEDV and has identified several targets of potential importance for developing control strategies.

Documents

Final Report	View - 2014.1455_MSU_Faisal_Final_Report.pdf
Appendices I and II	View - 2014.1455_MSU_Appendices_I_and_II.pdf
Appendices III and IV	View - 2014.1455_MSU_Appendices_III_and_IV.pdf
Appendices V and VI	View - 2014.1455_MSU_Appendices_V_and_VI.pdf
Appendices VII and VIII	View - 2014.1455_MSU_Appendices_VII_and_VIII.pdf
Appendix IX	View - 2014.1455_MSU_Appendix_IX.pdf